GLP-1(S).
Semaglutide is a synthetic analog of human glucagon-like peptide-1 (GLP-1) with 94% homology to native GLP-1. With the molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and a molecular weight of 4113.6 g/mol (CAS: 910...
Lab Verified
Clinical Grade
PMID Cited
Mechanism of Action.
Published preclinical research has characterized the following molecular pathways and receptor interactions for GLP-1(S).
GLP-1 Receptor
Semaglutide binds to GLP-1 receptors with high affinity, activating Gs-proteins and increasing intracellular cAMP levels in beta-cell models.
Albumin Binding
The C18 fatty di-acid side chain enables reversible albumin binding, extending circulation half-life in biochemical studies.
Receptor Internalization
Published studies indicate Semaglutide promotes receptor internalization with distinct kinetics compared to native GLP-1.
Clinical Literature
Research review on GLP-1(S) molecular characterization.
Preclinical studies have characterized the molecular properties and receptor binding profiles of GLP-1(S) in standardized assay systems.
GLP-1(S) structure-activity relationship analysis.
Structure-activity relationship studies have examined the functional domains and binding characteristics of GLP-1(S) in cell-free and cell-based systems.
Compound Data
| CAS Number | 910463-68-2 |
|---|---|
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.58 g/mol |
| Purity | ≥99% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | −20°C · Lyophilized |
GLP-1(S) Questions
What is GLP-1(S) used for?
GLP-1(S) is a research compound studied in laboratory settings. It has molecular formula C187H291N45O59, a molecular weight of 4113.58 g/mol, CAS 910463-68-2. Scientific literature has explored its properties in preclinical studies. For research purposes only. Not for human use.
What purity level does Evo Amino's GLP-1(S) have?
Evo Amino supplies GLP-1(S) at ≥99% purity, verified by third-party HPLC and mass spectrometry analysis. Certificates of Analysis are available upon request.
How is GLP-1(S) supplied?
GLP-1(S) is supplied as a lyophilized powder in sealed research-grade vials, intended for in vitro and laboratory research use only.
RESEARCH USE ONLY: This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. Not evaluated by the FDA. Must be 21+ to purchase.
Related Compounds.
Metabolic5-Amino-1MQ
$36.00C10H11N2 (free base) · 159.21 g/mol (free base)
For in vitro research use only. Not for human consumption.
MetabolicAICAR
$57.00C9H14N4O5 · 258.23 g/mol
For in vitro research use only. Not for human consumption.
MetabolicAOD9604
$48.00C78H123N23O23S2 · 1815.12 g/mol
For in vitro research use only. Not for human consumption.
Related Research & Analysis
GLP-1 Sequence, Molecular Weight, and Structure: A Reference FAQ
GLP-1 (7-37) is a 31-residue peptide, HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG, with the molecular formula C₁₅₁H₂₂₆N₄₀O₄₆ and a molecular weight of 3337.73 g/mol (CAS 106612-94-6). Twelve reference questions on its sequence, the 7-36 amide variant, proglucagon processing, DPP-4 cleavage, fusion proteins, and how analogs change the mass. For research purposes only.
BPC-157 vs GLP-1: Structural Classes, Mechanisms, and Research Applications Compared
A head-to-head structural and mechanistic comparison of BPC-157 and GLP-1 across their distinct research classes, receptor biology, and documented in vitro applications. For research purposes only.
How GLP-1 Receptor Binding Is Measured: Assay Methods and Their Limits
Radioligand binding, fluorescence polarization, surface plasmon resonance, BRET, and structural methods each answer a different question about receptor engagement. What each measures, what Kd and competition data establish, and where the methods disagree. For research purposes only.